- 专利标题： ENGINEERED OUTER DOMAIN (EOD) OF HIV GP120 AND MUTANTS THEREOF
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申请号： US16291726申请日： 2019-03-04
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公开(公告)号： US20190194262A1公开(公告)日： 2019-06-27
- 发明人: Po-Ssu Huang , Joseph Graham Jardine , Sergey V. Menis , William Ray Schief , Neil P. King
- 申请人： University of Washington, Center For Commercialization , The Scripps Research Institute , International AIDS Vaccine Initiative
- 主分类号： C07K14/005
- IPC分类号： C07K14/005 ; A61K39/21 ; A61K39/12 ; A61K38/00 ; G01N33/564
摘要：
The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
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