发明申请
- 专利标题： AZADECALIN DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
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申请号： US16307632申请日： 2017-06-28
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公开(公告)号： US20190209550A1公开(公告)日： 2019-07-11
- 发明人: Jie CHEN , Nicholas A. MEANWELL , Alicia REGUEIRO-REN , Sing-Yuen SIT , Jacob SWIDORSKI , Yan CHEN
- 申请人： VIIV HEALTHCARE UK (NO. 5) LIMITED
- 国际申请： PCT/IB2017/053879 WO 20170628
- 主分类号： A61K31/4725
- IPC分类号： A61K31/4725 ; A61K31/5365 ; A61K45/06 ; A61K31/496 ; C07D217/06 ; A61K31/541 ; A61K31/53 ; C07D417/14 ; C07D401/12 ; C07D417/12 ; C07D471/04 ; C07D473/28 ; A61K31/522 ; C07D405/12 ; C07D487/04 ; C07D495/04 ; C07D401/14 ; C07D413/12 ; C07D407/12 ; C07D471/08 ; C07D487/08 ; C07D453/00 ; A61K31/4748 ; C07D491/056 ; A61P31/18
摘要：
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, azadecaline derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: These compounds are useful for the treatment of HIV and AIDS.
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