A method for management of a differential memory includes storing first logic data associated with a first informative content in an auxiliary memory module of the differential memory; storing third logic data associated with a second informative content in a second submodule of a main memory module by overwriting second logic data associated with the first informative content while maintaining the first logic data contained in a first submodule of the main memory module unaltered; when the third logic data is being stored, reading the first logic data from the auxiliary memory module in a single-ended mode in response to a request for reading the first informative content; otherwise, reading the first logic data from the first submodule; and reading the third logic data in single-ended mode.