发明申请
- 专利标题: ANTIBODY LIKE PROTEIN
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申请号: US16445121申请日: 2019-06-18
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公开(公告)号: US20190316275A1公开(公告)日: 2019-10-17
- 发明人: Michael Longo , Rajika Perera
- 申请人: IDEA ORCHARD, LLC
- 主分类号: C40B40/10
- IPC分类号: C40B40/10 ; C12N15/10 ; C40B10/00 ; C40B40/08
摘要:
A general method and recombinant nucleic acid sequences, by means which the method selects a recombinant protein containing an FHA domain for binding a target molecule from a library proteins with a high-throughput method of creating protein variations within the FHA domain in non-conserved or non-structural sequences of the FHA scaffold, and the library may also be in the form of a phagemid or phage library wherein the ALP nucleic acid sequence is inserted into a vector capable of allowing the vector and expressed ALP protein from being virally packaged, and the recombinant nucleic acid sequences which are randomly mutated at varying non-conserved or non-structural FHA domain sequences.
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