- 专利标题： DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM
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申请号： US16456714申请日： 2019-06-28
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公开(公告)号： US20190367509A1公开(公告)日： 2019-12-05
- 发明人: Elena BRASOLA , Filippo Tomasi , Loris Peruzzi
- 申请人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
- 优先权： EP15177517.8 20150720
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; B01D11/02 ; C07B63/00 ; C07D413/14 ; G01N30/36 ; G01N30/72 ; C07D413/04
摘要：
Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.
公开/授权文献
- US10590133B2 Dimer impurities of Apixaban and method to remove them 公开/授权日：2020-03-17
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