- 专利标题： Macrocyclic MCL-1 Inhibitors and Methods of Use
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申请号： US16575114申请日： 2019-09-18
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公开(公告)号： US20200010480A1公开(公告)日： 2020-01-09
- 发明人: Patrick B. Brady , Wilfried Braje , Yujia Dai , George A. Doherty , Jane Gong , Katja Jantos , Cheng Ji , Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Anthony Mastracchio , Roberto M. Risi , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Jesse A. Teske , Xilu Wang , Michael D. Wendt , Yiyun Yu , Guidong Zhu , Thomas D. Penning
- 申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; A61P35/00 ; C07D519/00 ; C07D495/18 ; C07D495/16
摘要：
The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
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