According to one embodiment, a system establishes a secure connection between a host system and a data processing (DP) accelerator over a bus, the secure connection including one or more data channels. The system transmits a first instruction from the host system to the DP accelerator over a command channel, the first instruction requesting the DP accelerator to perform a data preparation operation. The system receives a first request to read a first data from a first memory location of the host system from the DP accelerator over one data channel. In response to the request, the system transmits the first data to the DP accelerator over the data channel, where the first data is utilized for a computation or a configuration operation. The system transmits a second instruction from the host system to the DP accelerator over the command channel to perform the computation or the configuration operation.