An interrupt management system and a management method thereof are provided. The interrupt management system includes a processor and an interrupt signal expanding controller. The processor receives a plurality of original interrupt signals. The interrupt signal expanding controller includes a decoder and an interrupt vector table. The decoder receives a plurality of expanding interrupt request signals, and decodes the expanding interrupt request signals to generate the original interrupt signals, where number of the expanding interrupt request signals is larger than number of the original interrupt signals. The interrupt vector table stores a plurality of interrupt vectors. The decoder reads one of the interrupt vectors to obtain an accessed interrupt vector according to the expanding interrupt request signals, and the interrupt signal expanding controller transmits the accessed interrupt vector to the processor.