- 专利标题： Antibody Drug Conjugates with Cell Permeable BCL-XL Inhibitors
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申请号： US16412729申请日： 2019-05-15
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公开(公告)号： US20200246323A1公开(公告)日： 2020-08-06
- 发明人: Scott L. Ackler , Erwin R. Boghaert , Milan Bruncko , George Doherty , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-fu Tao , Xilu Wang , Dennle S. Welch
- 申请人： AbbVie Inc.
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; A61K47/68
摘要：
Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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