公开(公告)号：US20200246323A1

公开(公告)日：2020-08-06

申请号：US16412729

申请日：2019-05-15

Applicant: AbbVie Inc.

Inventor： Scott L. Ackler ,  Erwin R. Boghaert ,  Milan Bruncko ,  George Doherty ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Violeta L. Marin ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-fu Tao ,  Xilu Wang ,  Dennle S. Welch

IPC: A61K31/4545 ,  A61K47/68

Abstract: Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.