- 专利标题： HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
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申请号： US16646616申请日： 2018-09-14
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公开(公告)号： US20200262826A1公开(公告)日： 2020-08-20
- 发明人: Ian M. Bell , Brendan M. Crowley , Peter J. Manley , William D. Shipe
- 申请人： Ian M. BELL , Brendan M. CROWLEY , Peter J. MANLEY , William D. SHIPE , Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US2018/050975 WO 20180914
- 主分类号： C07D413/08
- IPC分类号： C07D413/08 ; C07D413/14 ; C07D417/08 ; C07D417/14 ; A61P25/28 ; A61P25/16 ; A61P25/18
摘要：
The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
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