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公开(公告)号：US20200262826A1
公开(公告)日：2020-08-20
申请号：US16646616
申请日：2018-09-14
申请人： Ian M. BELL , Brendan M. CROWLEY , Peter J. MANLEY , William D. SHIPE , Merck Sharp & Dohme Corp.
IPC分类号： C07D413/08 , C07D413/14 , C07D417/08 , C07D417/14 , A61P25/28 , A61P25/16 , A61P25/18
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
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公开(公告)号：US20220396571A1
公开(公告)日：2022-12-15
申请号：US17771527
申请日：2020-10-29
IPC分类号： C07D417/08 , A61K31/454 , C07D413/14 , C07D401/14 , A61K31/4545 , A61K31/506
摘要： The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
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公开(公告)号：US20220235041A1
公开(公告)日：2022-07-28
申请号：US17619338
申请日：2020-06-02
申请人： Brendan M. CROWLEY , Philippe NANTERMET , David OLSEN , Takao SUZUKI , Merck Sharp & Dohme Corp.
IPC分类号： C07D413/14 , C07D413/12 , C07D417/10 , A61K31/422 , A61K31/541 , C07D471/04 , A61K31/437 , C07D413/10 , A61K45/06 , A61P31/06 , A61P31/08
摘要： Disclosed are dihydroisoxazole compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. Also disclosed are compositions which comprise at least one of these dihydroisoxazole compounds, methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of these dihydroisoxazole compounds and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
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4.发明授权公开(公告)号：US11026958B2
公开(公告)日：2021-06-08
申请号：US16345997
申请日：2017-10-30
发明人： Brendan M. Crowley , Ian M. Bell , Andrew John Harvey , Brian T. Campbell , Thomas J. Greshock , Vanessa L. Rada
IPC分类号： A61K31/695 , A61K31/198 , C07D213/34 , C07D413/04 , C07D239/26 , C07D401/04 , C07D271/06 , C07D233/64 , C07D249/08 , A61K31/4418 , A61K31/5377 , A61K31/505 , A61K31/4439 , A61K31/4245 , A61K31/506 , A61K31/50 , A61K31/4965 , C07D237/08 , C07D241/12 , C07F7/08 , A61K31/4196 , A61K31/4164 , A61K45/06
摘要： The present disclosure relates to compounds of formula (I) that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
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5.发明申请公开(公告)号：US20210196734A1
公开(公告)日：2021-07-01
申请号：US17193550
申请日：2021-03-05
发明人： Brendan M. Crowley , Ian M. Bell , Andrew John Harvey , Brian T. Campbell , Thomas J. Greshock , Vanessa L. Rada
IPC分类号： A61K31/695 , A61K31/198 , A61K31/4164 , A61K31/4196 , A61K31/4245 , A61K31/4418 , A61K31/4439 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/34 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D271/06 , C07D401/04 , C07D413/04 , C07F7/08
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：US09926285B2
公开(公告)日：2018-03-27
申请号：US15727982
申请日：2017-10-09
IPC分类号： C07D285/12 , C07D231/12 , C07D249/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/26 , C07D285/08 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , A61K31/415 , C07D271/107
CPC分类号： C07D285/12 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D285/08 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D495/04
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：US20220119351A1
公开(公告)日：2022-04-21
申请号：US17606154
申请日：2020-04-27
发明人： Ian M. Bell , Brian T. Campbell , Brendan M. Crowley , James Fells , Kenneth J. Leavitt , Anthony J. Roecker , Andrew John Harvey , Belinda C. Huff , Dharam Paul , Christophe Morice , Christophe Joseph , Patrick Bazzini , Jean-Marie Contreras , Fabrice Garrido , Aurelie Witzel
IPC分类号： C07D221/20 , C07D401/12 , A61K45/06 , A61K31/444 , A61K31/438 , C07D413/12 , C07D401/14
摘要： The present disclosure relates to compounds of formula (I) that are useful as modulators of 7α nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation.
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公开(公告)号：US20180030007A1
公开(公告)日：2018-02-01
申请号：US15727982
申请日：2017-10-09
发明人： Brendan M. Crowley , Brian T. Campbell , Joseph L. Duffy , Thomas J. Greshock , Deodial G. Guiadeen , Andrew John Harvey , Belinda C. Huff , Kenneth J. Leavitt , Vanessa L. Rada , John M. Sanders , William D. Shipe , Linda M. Suen , Ian M. Bell
IPC分类号： C07D285/12 , A61K31/415 , C07D271/107 , C07D271/06 , C07D263/32 , C07D261/08 , C07D249/04 , C07D231/12 , A61K31/433 , A61K31/426 , A61K31/4245 , A61K31/421 , A61K31/42 , A61K31/4192 , C07D277/26 , C07D285/08
CPC分类号： C07D285/12 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D285/08 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D495/04
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：US09840481B2
公开(公告)日：2017-12-12
申请号：US15463336
申请日：2017-03-20
发明人： Brendan M. Crowley , Brian T. Campbell , Joseph L. Duffy , Thomas J. Greshock , Deodial G. Guiadeen , Andrew John Harvey , Belinda C. Huff , Kenneth J. Leavitt , Vanessa L. Rada , John M. Sanders , William D. Shipe , Linda M. Suen , Ian M. Bell
IPC分类号： C07D285/12 , C07D231/12 , C07D249/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/07 , C07D277/26 , C07D285/08 , A61K31/4245 , A61K31/433 , C07D271/107 , A61K31/421 , A61K31/42 , A61K31/4192 , A61K31/415 , A61K31/426
CPC分类号： C07D285/12 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D231/12 , C07D233/64 , C07D249/04 , C07D249/06 , C07D249/08 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D271/107 , C07D277/26 , C07D285/08 , C07D413/04 , C07D413/06 , C07D413/10 , C07D417/04 , C07D495/04
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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公开(公告)号：US11198687B2
公开(公告)日：2021-12-14
申请号：US16646616
申请日：2018-09-14
IPC分类号： C07D413/08 , A61P25/28 , A61P25/18 , A61P25/16 , C07D413/14 , C07D417/08 , C07D417/14 , A61K45/06
摘要： The present disclosure relates to compounds of formula I that are useful as modulators of 7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation (I).
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