- 专利标题： TRIAZOLES FOR REGULATING INTRACELLULAR CALCIUM HOMEOSTASIS
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申请号： US16304041申请日： 2017-05-23
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公开(公告)号： US20200317625A1公开(公告)日： 2020-10-08
- 发明人: Ainara VALLEJO ILLARRAMENDI , Adolfo Jose LOPEZ DE MUNAIN ARREGI , Pablo FERRON CELMA , Jesus Maria AIZPURUA IPARRAGUIRRE , Aitziber IRASTORZA EPELDE , Jose Ignacio MIRANDA MURUA , Ivan TORAL OJEDA , Garazi ALDANONDO ARISTIZABAL
- 申请人： UNIVERSIDAD DEL PAIS VASCO , ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI
- 优先权： com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@57cc4048
- 国际申请： PCT/ES2017/070344 WO 20170523
- 主分类号： C07D249/04
- IPC分类号： C07D249/04 ; A61P21/00 ; A61P9/04
摘要：
The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.
公开/授权文献
- US11377427B2 Triazoles for regulating intracellular calcium homeostasis 公开/授权日：2022-07-05
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