公开(公告)号：US20200317625A1

公开(公告)日：2020-10-08

申请号：US16304041

申请日：2017-05-23

申请人： UNIVERSIDAD DEL PAIS VASCO ,  ADMINISTRACION GENERAL DE LA COMUNIDAD AUTONOMA DE EUSKADI

发明人： Ainara VALLEJO ILLARRAMENDI ,  Adolfo Jose LOPEZ DE MUNAIN ARREGI ,  Pablo FERRON CELMA ,  Jesus Maria AIZPURUA IPARRAGUIRRE ,  Aitziber IRASTORZA EPELDE ,  Jose Ignacio MIRANDA MURUA ,  Ivan TORAL OJEDA ,  Garazi ALDANONDO ARISTIZABAL

IPC分类号： C07D249/04 ,  A61P21/00 ,  A61P9/04

摘要： The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.