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公开(公告)号：US10888529B2
公开(公告)日：2021-01-12
申请号：US16091071
申请日：2017-04-04
摘要： The invention relates to a nanoparticle comprising: (i) between 60 wt.-% and 99 wt.-% sorbitan ester, relative to the total weight of the nanoparticle; (ii) a positively charged substance; and (iii) a miRNA. The invention also relates to the methods for producing same and to the uses thereof, particularly for therapeutic uses, such as cancer treatment.
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公开(公告)号：US09650536B2
公开(公告)日：2017-05-16
申请号：US14413166
申请日：2013-05-15
申请人： Akzo Nobel Coatings International B.V. , BYK-Chemie GmbH , Energenics Europe Ltd , Universidad del Pais Vasco , YKI, Ytkemiska Institutet AB
发明人： Nils Erik Ronne , Melanie Hormann , Janin Tecklenburg , Carsten Nagel , Ulrich Nolte , Michael Berkei , Yingqian Xu , Jose Ramon Leiza , Yuri Reyes , Maria Paulis , Miren Aguirre Arrese , Anwar Ahniyaz , Andrea Fornara , Ninja Hanitzsch
IPC分类号： C08F2/22 , C09D133/12 , C08J3/05 , C08J3/09 , C08J3/11 , C08F2/44 , C08J5/00 , C09D133/06 , B82Y30/00 , C09D129/04 , C09D131/04 , C08F2/24
CPC分类号： C09D133/12 , B82Y30/00 , C08F2/22 , C08F2/24 , C08F2/44 , C08J3/05 , C08J3/09 , C08J3/092 , C08J3/11 , C08J5/005 , C09D129/04 , C09D131/04 , C09D133/06 , C08K9/06 , C08K9/04 , C09J131/04 , C08F220/14 , C08F2220/1825 , C08F220/06 , C08F2220/1891
摘要： The present invention relates to a method for producing nanocomposite dispersions comprising composite particles of inorganic nanoparticles and organic polymers in a continuous phase, especially in a dispersion medium, as well as to the nanocomposite dispersions thus obtained and to the use thereof.
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公开(公告)号：US20160289256A1
公开(公告)日：2016-10-06
申请号：US15038381
申请日：2014-11-18
CPC分类号： C07G1/00 , C07C27/00 , C07C37/54 , C07C37/72 , C07C41/01 , C07C41/18 , C07C41/38 , C07C45/59 , C07C45/673 , C07C45/80 , C07C39/04 , C07C39/07 , C07C39/08 , C07C47/58 , C07C43/23
摘要： A method for the depolymerization of lignin includes the steps of: providing a black liquor obtained from the treatment of delignification of the biomass, concentrating the black liquor; and subjecting the concentrated black liquor to a hydrothermal treatment. An acid is added to the reaction mixture obtained in the previous step, and then the precipitate is separated from the liquid phase resulting in the previous step. Finally, the method includes the step of extracting, from the recovered liquid phase, the aromatic products of depolymerization of lignin, such as phenol, cresols, catechol and the derivatives thereof (3-methylcatechol, 4-methylcatechol and 4-ethylcatechol).
摘要翻译： 木质素解聚方法包括以下步骤：提供从处理生物质脱木质得到的黑液，浓缩黑液; 并对浓缩的黑液进行水热处理。 向前一步骤中获得的反应混合物中加入酸，然后将沉淀物从液相中分离出来，得到上一步骤。 最后，该方法包括从回收液相中提取木质素如苯酚，甲酚，邻苯二酚及其衍生物（3-甲基儿茶酚，4-甲基儿茶酚和4-乙基儿茶酚）的解聚芳香族产物的步骤。
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公开(公告)号：US20160113995A1
公开(公告)日：2016-04-28
申请号：US14985532
申请日：2015-12-31
申请人： BIOPRAXIS RESEARCH AIE , PRAXIS PHARMACEUTICAL, S.A. , FUNDACIO D'INVESTIGACIO SANITARIA DE LES ILLES BALEARS , UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA , UNIVERSIDAD DE BARCELONA , CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
发明人： Eusebio GAINZA LAFUENTE , Angel DEL POZO PEREZ , Garazi GAINZA LUCEA , Oihane IBARROLA MORENO , Silvia VILLULLAS RINCON , Raul FERNANDEZ PLAGARO , Daniel BACHILLER PEREZ , Jose Luis PEDRAZ MUNOZ , Amaya ESQUISABEL ALEGRIA , Marta PASTOR NAVARRO , Ester FUSTE DOMINGUEZ , Eulalia SANS SERRAMIT JANA , Iraida GIL MARTIN
CPC分类号： A61K38/12 , A61K9/0073 , A61K9/5123
摘要： A lipid nanoparticle that includes at least one antibiotic from the polymyxin family, a lipid fraction, and one or more surfactants. The lipid nanoparticle is useful in the prevention and/or treatment of respiratory tree infections.
摘要翻译： 包含来自多粘菌素家族的至少一种抗生素，脂质部分和一种或多种表面活性剂的脂质纳米颗粒。 脂质纳米颗粒可用于预防和/或治疗呼吸道感染。
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5.发明申请公开(公告)号：US20160053042A1
公开(公告)日：2016-02-25
申请号：US14758157
申请日：2013-12-26
申请人： UNIVERSIDAD DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA , CENTRO DE INVESTIGACIÓN BIOMEDICA EN RED , FUNDACION TECNALIA RESEARCH & INNOVATION
发明人： Jesús María Aizpurua Iparraguirre , Maialen Sagartzazu Aizpurua , Iñigo Braceras Izaguirre , Francisco Javier Azpiroz Dorronsoro , Joseba Oyarbide Vicuña
CPC分类号： C08G8/28 , A61L27/18 , A61L27/56 , A61L2300/25 , A61L2300/412 , A61L2400/18 , A61L2430/02 , A61L2430/24 , A61L2430/38 , C08G65/48 , C08G2650/40 , C08J9/36 , C08J2361/16 , C09K11/06 , C09K2211/1416 , C09K2211/1466 , C08L71/00
摘要： The present invention relates to a modified polyaryletherketone polymer (PAEK) with chemically modified surfaces with azides, alkynes, thiols, maleimides, sulfonylazides or thio acids, suitable for “click” reactions and to a process to obtain it. It also relates to the conjugated biomaterials derived thereof, PAEK type materials with surfaces modified with a RGD (Arg-Gly-Asp) and/or OGP10-14 (Tyr-Gly-Phe-Gly-Gly) peptidomimetics and to a process to obtain it. These materials are particularly useful for manufacturing medical devices. Finally, the present invention also relates to a fluorescent PAEK material.
摘要翻译： 本发明涉及具有化学修饰表面的改性聚芳醚酮聚合物（PAEK），其具有适用于“点击”反应的叠氮化物，炔，硫醇，马来酰亚胺，磺酰基叠氮化物或硫代酸，以及获得该反应的方法。 它还涉及其衍生的共轭生物材料，具有用RGD（Arg-Gly-Asp）和/或OGP10-14（Tyr-Gly-Phe-Gly-Gly）肽模拟物修饰的表面的PAEK型材料，以及获得 它。 这些材料对于制造医疗装置特别有用。 最后，本发明还涉及一种荧光PAEK材料。
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公开(公告)号：US20150157723A1
公开(公告)日：2015-06-11
申请号：US14097488
申请日：2013-12-05
申请人： International Business Machines Corporation , Universidad del Pais Vasco/Euskal Herriko Unibertsitatea , Agency For Science, Technology and Research
发明人： Julian M. W. Chan , Amanda C. Engler , James L. Hedrick , Xiyu Ke , Victor W.L. Ng , Haritz Sardon , Jeremy P. K. Tan , Yi Yan Yang
IPC分类号： A61K47/34 , A61K31/713 , A61K31/704 , A61K38/16
CPC分类号： A61K47/34 , A61K9/5146 , A61K31/704 , A61K31/713 , A61K38/00 , A61K38/16 , C08G64/0241 , C08G64/183 , C08L69/00
摘要： Nanoparticles comprise a drug, a first block polymer and a second block polymer. The first block polymer has a poly(ethylene oxide) (PEO) block and a polycarbonate block bearing a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle can be in the form of a base, a hydrosalt of the base, a sulfobetaine adduct of the base, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block bearing a side chain catechol group, which can be present as a catechol, oxidized form of a catechol, and/or a polymerized form of a catechol. The nanoparticles can be dispersed in water and are capable of controlled release of the drug.
摘要翻译： 纳米颗粒包含药物，第一嵌段聚合物和第二嵌段聚合物。 第一嵌段聚合物具有聚（环氧乙烷）（PEO）嵌段和带有侧链芳香族含氮杂环（N-杂环）的聚碳酸酯嵌段）。 N-杂环可以是碱的形式，碱的氢盐，碱的磺基甜菜碱加合物或其组合。 第二嵌段聚合物具有PEO嵌段和带有侧链儿茶酚基团的聚碳酸酯嵌段，其可以儿茶酚，氧化形式的儿茶酚和/或邻苯二酚的聚合形式存在。 纳米颗粒可以分散在水中并且能够控制释放药物。
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7.发明公开公开(公告)号：US20240277695A1
公开(公告)日：2024-08-22
申请号：US17928273
申请日：2021-05-27
申请人： Administración General de la Comunidad Autónoma de Euskadi , Universidad Del Pais Vasco/Euskal Herriko Unibersitatea
发明人： Mónica Zufiría García , Gorka Gereñu Lopetegi , Patxi Gil Bea , Sonia Alonso Martin , Jaione Lasa Elgarresta , Adolfo López de Munain Arregui , Jesús María Aizpurua Iparraguirre , José Ignacio Miranda Murua
IPC分类号： A61K31/4709 , A61K31/47 , A61P25/28
CPC分类号： A61K31/4709 , A61K31/47 , A61P25/28
摘要： FoxO inhibitors for use in the treatment of diseases caused by abnormal TDP-43 and/or FUS proteins. The present invention refers to FoxO inhibitors, preferably quinolone derivatives, for use in the treatment of diseases caused by alterations of TDP-43 and/or FUS proteins, preferably Amyotrophic lateral sclerosis (ALS).
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公开(公告)号：US20240052175A1
公开(公告)日：2024-02-15
申请号：US18268761
申请日：2021-12-21
IPC分类号： C09D4/00 , C09D189/00 , A61L31/04 , B33Y70/00
CPC分类号： C09D4/00 , C09D189/00 , A61L31/047 , A61L31/048 , B33Y70/00 , B33Y10/00
摘要： Disclosed herein are compositions comprising globular proteins and diacrylate-containing compounds that can react in-situ to provide polymerized networks that can be formed into objects using additive manufacturing techniques, such as printing techniques that use vat photopolymerization. Objects printed using the disclosed compositions also are described, with embodiments of such objects exhibiting shape recovery behavior. Also disclosed are methods of making and using the disclosed compositions.
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公开(公告)号：US20200317625A1
公开(公告)日：2020-10-08
申请号：US16304041
申请日：2017-05-23
发明人： Ainara VALLEJO ILLARRAMENDI , Adolfo Jose LOPEZ DE MUNAIN ARREGI , Pablo FERRON CELMA , Jesus Maria AIZPURUA IPARRAGUIRRE , Aitziber IRASTORZA EPELDE , Jose Ignacio MIRANDA MURUA , Ivan TORAL OJEDA , Garazi ALDANONDO ARISTIZABAL
IPC分类号： C07D249/04 , A61P21/00 , A61P9/04
摘要： The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.
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公开(公告)号：US20190111002A1
公开(公告)日：2019-04-18
申请号：US16091071
申请日：2017-04-04
申请人： UNIVERSIDADE DE SANTIAGO DE COMPOSTELA , UNIVERSIDAD DEL PAIS VASCO - EUSKAL HERRIKO UNIBERTSITATEA (UPV/EHU)
IPC分类号： A61K9/51 , A61K31/7105
摘要： The invention relates to a nanoparticle comprising: (i) between 60 wt.-% and 99 wt.-% sorbitan ester, relative to the total weight of the nanoparticle; (ii) a positively charged substance; and (iii) a miRNA. The invention also relates to the methods for producing same and to the uses thereof, particularly for therapeutic uses, such as cancer treatment.
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