发明申请
- 专利标题: EPSTEIN-BARR VIRUS VACCINES
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申请号: US16922322申请日: 2020-07-07
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公开(公告)号: US20200330587A1公开(公告)日: 2020-10-22
- 发明人: Masaru Kanekiyo , Gary J. Nabel , Jeffrey Cohen , Wei Bu
- 申请人: The USA, as represented by the Secretary, Dept. of Health and Human Services
- 主分类号: A61K39/245
- IPC分类号: A61K39/245 ; A61K39/12 ; C07K14/00 ; C07K14/005 ; C07K14/195 ; C07K16/08 ; C12N7/00
摘要:
Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
公开/授权文献
- US12005115B2 Epstein-barr virus vaccines 公开/授权日:2024-06-11
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