发明申请
US20200338124A1 CELL
审中-公开
- 专利标题: CELL
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申请号: US16613364申请日: 2018-05-14
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公开(公告)号: US20200338124A1公开(公告)日: 2020-10-29
- 发明人: Shaun Cordoba , Evangelia Kokalaki , Martin Pulé , Simon Thomas , Shimobi Onuoha
- 申请人: AUTOLUS LIMITED
- 优先权: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@6062e371
- 国际申请: PCT/GB18/51294 WO 20180514
- 主分类号: A61K35/17
- IPC分类号: A61K35/17 ; C07K16/28 ; C07K14/725 ; C07K14/705 ; C12N15/86
摘要:
The present invention provides a cell which co-expresses a first chimeric antigen receptor (CAR) and second CAR wherein the first CAR comprises an activating endodomain and the second CAR comprises an inhibitory endodomain, wherein the inhibitory endodomain comprises C-terminal Src Kinase (CSK).
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