Invention Application
- Patent Title: METHODS AND COMPOSITIONS FOR MODULATING MYELOPEROXIDASE (MPO) EXPRESSION
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Application No.: US17257764Application Date: 2019-07-04
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Publication No.: US20210121539A1Publication Date: 2021-04-29
- Inventor: Anat KAHANA , Rotem VOLKMAN , Ben Zion GARTY , Daniel OFFEN
- Applicant: LEMPO THERAPEUTICS LTD , RAMOT AT TEL-AVIV UNIVERSITY LTD.
- Applicant Address: IL Binyamina; IL Tel Aviv
- Assignee: LEMPO THERAPEUTICS LTD,RAMOT AT TEL-AVIV UNIVERSITY LTD.
- Current Assignee: LEMPO THERAPEUTICS LTD,RAMOT AT TEL-AVIV UNIVERSITY LTD.
- Current Assignee Address: IL Binyamina; IL Tel Aviv
- Priority: IL260445 20180705
- International Application: PCT/IL2019/050745 WO 20190704
- Main IPC: A61K38/46
- IPC: A61K38/46 ; A61K35/28 ; A61K31/7105 ; C12N15/90 ; A61P37/06 ; A61P25/28
Abstract:
The present invention relates to methods of modulating the expression and/or activity of Myeloperoxidase (MPO) in a mammalian subject, by modulating ex vivo and/or in vivo MPO levels and/or activity in undifferentiated bone marrow (BM) cells of the subject. The invention further provide therapeutic methods and compositions for treating MPO-related disorders.
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