公开(公告)号：US20210121539A1

公开(公告)日：2021-04-29

申请号：US17257764

申请日：2019-07-04

Applicant: LEMPO THERAPEUTICS LTD ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Anat KAHANA ,  Rotem VOLKMAN ,  Ben Zion GARTY ,  Daniel OFFEN

IPC: A61K38/46 ,  A61K35/28 ,  A61K31/7105 ,  C12N15/90 ,  A61P37/06 ,  A61P25/28

Abstract: The present invention relates to methods of modulating the expression and/or activity of Myeloperoxidase (MPO) in a mammalian subject, by modulating ex vivo and/or in vivo MPO levels and/or activity in undifferentiated bone marrow (BM) cells of the subject. The invention further provide therapeutic methods and compositions for treating MPO-related disorders.

公开(公告)号：US20210214699A1

公开(公告)日：2021-07-15

申请号：US17142072

申请日：2021-01-05

Applicant: LEMPO THERAPEUTICS LTD ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Anat KAHANA ,  Rotem VOLKMAN ,  Ben Zion GARTY ,  Daniel OFFEN

IPC: C12N9/22 ,  C12N15/113 ,  C12N5/077

Abstract: The present invention relates to methods of modulating the expression and/or activity of Myeloperoxidase (MPO) in a mammalian subject, by modulating ex vivo and/or in vivo MPO levels and/or activity in undifferentiated bone marrow (BM) cells of the subject. The invention further provides therapeutic methods and compositions for treating MPO-related disorders.