- 专利标题: DEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE
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申请号: US17042711申请日: 2019-03-29
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公开(公告)号: US20210147624A1公开(公告)日: 2021-05-20
- 发明人: Hiroki YOSHIOKA , Masaki KAMIYA , Yuji YAMAMOTO , Midori HIRAI , Akiko SASAKI , Nobuhiro NISHIYAMA , Makoto MATSUI , Hiroyasu TAKEMOTO , Kazuki MIYAUCHI , Takahiro NOMOTO , Keishiro TOMODA
- 申请人: NOF CORPORATION , TOKYO INSTITUTE OF TECHNOLOGY
- 申请人地址: JP Tokyo; JP Tokyo
- 专利权人: NOF CORPORATION,TOKYO INSTITUTE OF TECHNOLOGY
- 当前专利权人: NOF CORPORATION,TOKYO INSTITUTE OF TECHNOLOGY
- 当前专利权人地址: JP Tokyo; JP Tokyo
- 优先权: JP2018-064305 20180329
- 国际申请: PCT/JP2019/014246 WO 20190329
- 主分类号: C08G65/333
- IPC分类号: C08G65/333 ; C08G65/325 ; A61K47/65
摘要:
The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.