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公开(公告)号：US20210147624A1
公开(公告)日：2021-05-20
申请号：US17042711
申请日：2019-03-29
发明人： Hiroki YOSHIOKA , Masaki KAMIYA , Yuji YAMAMOTO , Midori HIRAI , Akiko SASAKI , Nobuhiro NISHIYAMA , Makoto MATSUI , Hiroyasu TAKEMOTO , Kazuki MIYAUCHI , Takahiro NOMOTO , Keishiro TOMODA
IPC分类号： C08G65/333 , C08G65/325 , A61K47/65
摘要： The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.
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公开(公告)号：US20210023231A1
公开(公告)日：2021-01-28
申请号：US17042039
申请日：2019-03-29
发明人： Hiroki YOSHIOKA , Masaki KAMIYA , Yuji YAMAMOTO , Midori HIRAI , Akiko SASAKI , Nobuhiro NISHIYAMA , Makoto MATSUI , Hiroyasu TAKEMOTO , Kazuki MIYAUCHI , Takahiro NOMOTO , Keishiro TOMODA
IPC分类号： A61K47/60 , C08G65/333 , C07K19/00 , C07K5/103 , C07K7/06 , A61K38/23 , A61K38/19 , A61K38/27
摘要： The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A):
wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.
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