公开(公告)号：US20220387609A1

公开(公告)日：2022-12-08

申请号：US17599402

申请日：2020-03-26

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki YOSHIOKA ,  Kazuki OSAKAMA ,  Mika HAMURA ,  Takanori INABA ,  Nobuhiro NISHIYAMA ,  Makoto MATSUI ,  Hiroyasu TAKEMOTO ,  Takahiro NOMOTO ,  Xiaohang SUN

IPC: A61K47/64 ,  A61K47/60

Abstract: A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.

公开(公告)号：US20220153992A1

公开(公告)日：2022-05-19

申请号：US17599163

申请日：2020-03-26

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki YOSHIOKA ,  Kazuki OSAKAMA ,  Mika HAMURA ,  Takanori INABA ,  Nobuhiro NISHIYAMA ,  Makoto MATSUI ,  Hiroyasu TAKEMOTO ,  Takahiro NOMOTO ,  Xiaohang SUN

IPC: C08L71/02 ,  C08G65/333 ,  C08L101/16

Abstract: An intracellularly degraded branched and degradable polyethylene glycol derivative represented by the following formula (1): wherein each symbol is as defined in the present specification, that is used for modifying bio-related substances is provided by the present invention.

公开(公告)号：US20210023231A1

公开(公告)日：2021-01-28

申请号：US17042039

申请日：2019-03-29

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki YOSHIOKA ,  Masaki KAMIYA ,  Yuji YAMAMOTO ,  Midori HIRAI ,  Akiko SASAKI ,  Nobuhiro NISHIYAMA ,  Makoto MATSUI ,  Hiroyasu TAKEMOTO ,  Kazuki MIYAUCHI ,  Takahiro NOMOTO ,  Keishiro TOMODA

IPC: A61K47/60 ,  C08G65/333 ,  C07K19/00 ,  C07K5/103 ,  C07K7/06 ,  A61K38/23 ,  A61K38/19 ,  A61K38/27

Abstract: The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A):
wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

公开(公告)号：US20240374733A1

公开(公告)日：2024-11-14

申请号：US18577158

申请日：2022-07-06

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Koichi OGI ,  Junya MICHINISHI ,  Tomoyuki OHTAKE ,  Nobuhiro NISHIYAMA ,  Hiroyasu TAKEMOTO ,  Yutaka MIURA ,  Takahiro NOMOTO ,  Makoto MATSUI ,  Yi-Jung SUNG ,  Masahiro TOYODA ,  Aria GHASEMIZADEH

IPC: A61K47/34 ,  A61K31/7088 ,  A61K38/02 ,  C08G69/10 ,  C12N15/115

Abstract: The present invention provides a pH-responsive lipid derivative represented by a structure represented by the following formula (i): (in the above-mentioned formula, each symbol is as described in the specification), and a pH-responsive transport carrier which is useful as a transport carrier for safely and efficiently performing delivery of low-molecular-weight drugs and the like to tumor tissues.

公开(公告)号：US20240301137A1

公开(公告)日：2024-09-12

申请号：US18577166

申请日：2022-07-06

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Koichi OGI ,  Junya MICHINISHI ,  Tomoyuki OHTAKE ,  Muneaki IIZUKA ,  Nobuhiro NISHIYAMA ,  Hiroyasu TAKEMOTO ,  Yutaka MIURA ,  Takahiro NOMOTO ,  Makoto MATSUI ,  Yi-Jung SUNG ,  Masahiro TOYODA ,  Aria GHASEMIZADEH

IPC: C08G69/48 ,  C08G69/08 ,  C08G69/46

CPC classification number: C08G69/48 ,  C08G69/08 ,  C08G69/46

Abstract: The present invention provides a highly pure pH-responsive polymer represented by the following formula (I), a production method thereof, and the like:




(in the formula (I), each symbol is as described in the specification).

公开(公告)号：US20210147624A1

公开(公告)日：2021-05-20

申请号：US17042711

申请日：2019-03-29

Applicant: NOF CORPORATION ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hiroki YOSHIOKA ,  Masaki KAMIYA ,  Yuji YAMAMOTO ,  Midori HIRAI ,  Akiko SASAKI ,  Nobuhiro NISHIYAMA ,  Makoto MATSUI ,  Hiroyasu TAKEMOTO ,  Kazuki MIYAUCHI ,  Takahiro NOMOTO ,  Keishiro TOMODA

IPC: C08G65/333 ,  C08G65/325 ,  A61K47/65

Abstract: The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer.

公开(公告)号：US20220211646A1

公开(公告)日：2022-07-07

申请号：US17605027

申请日：2020-04-23

Applicant: Tokyo Institute of Technology ,  SBI Pharmaceuticals Co., Ltd.

Inventor： Nobuhiro NISHIYAMA ,  Takahiro NOMOTO ,  Kana KOHMOTO ,  Hiroyasu TAKEMOTO ,  Makoto MATSUI

IPC: A61K31/16 ,  A61K47/64 ,  A61P35/00

Abstract: A conjugate is provided in which a deferoxamine-type compound, which is at least one compound selected from the group consisting of deferoxamine or an ion or salt thereof, and a derivative thereof, and a biocompatible polymer are conjugated, where the biocompatible polymer contains a first biocompatible polymer chain and a second biocompatible polymer chain that is different from the first biocompatible polymer chain.

公开(公告)号：US20210040244A1

公开(公告)日：2021-02-11

申请号：US16963864

申请日：2019-02-19

Applicant: TOKYO INSTITUTE OF TECHNOLOGY ,  STELLA PHARMA CORPORATION

Inventor： Nobuhiro NISHIYAMA ,  Takahiro NOMOTO ,  Yukiya INOUE ,  Ying YAO ,  Kaito KANAMORI ,  Hiroyasu TAKEMOTO ,  Makoto MATSUI ,  Keishiro TOMODA

IPC: C08F8/42 ,  A61P35/00 ,  C08F16/06 ,  A61K47/60 ,  A61K31/69 ,  A61K9/00

Abstract: The present invention pertains to: a p-boronophenylalanine derivative that comprises a polymer to which a group represented by formula (I) is linked directly or via a linker; a composition containing same; and a kit for producing said derivative and composition.

公开(公告)号：US20200261476A1

公开(公告)日：2020-08-20

申请号：US16067906

申请日：2017-01-05

Applicant: KEIO UNIVERSITY ,  TOKYO INSTITUTE OF TECHNOLOGY

Inventor： Hideyuki SAYA ,  Osamu NAGANO ,  Kenji TSUCHIHASHI ,  Kentaro SUINA ,  Nobuhiro NISHIYAMA ,  Hiroyasu TAKEMOTO ,  Takahiro NOMOTO ,  Makoto MATSUI ,  Keishiro TOMODA ,  Naoki YAMADA ,  Tsukasa NISHIMORI

IPC: A61K31/635 ,  A61K47/60

Abstract: The present invention is directed to provide antitumor agent including water-soluble sulfasalazine as an active ingredient. Antitumor agents were obtained with, as the water-soluble sulfasalazine, a PEG-modified sulfasalazine represented by the following formula: wherein an average value of n is 4 or larger and 1136 or smaller.