![CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE](/docs/US/2021-06-03/US20210163523A1/abs.jpg.600x600.jpg)
- 专利标题： CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE
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申请号： US17069248申请日： 2020-10-13
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公开(公告)号： US20210163523A1公开(公告)日： 2021-06-03
- 发明人: Katrien Brak , Ernest A. Carra , Lars V. Heumann , Nate Larson
- 申请人： Gilead Sciences, Inc.
- 申请人地址： US CA Foster City
- 专利权人： Gilead Sciences, Inc.
- 当前专利权人： Gilead Sciences, Inc.
- 当前专利权人地址： US CA Foster City
- 主分类号： C07H19/00
- IPC分类号： C07H19/00 ; A61P31/14 ; C07F9/6561
![CRYSTALLINE FORMS OF (S)-2-ETHYLBUTYL 2-(((S)-(((2R,3S,4R,5R)-5- (4-AMINOPYRROLO[2,1-F] [1,2,4]TRIAZIN-7-YL)-5-CYANO-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHOXY) (PHENOXY) PHOSPHORYL)AMINO)PROPANOATE](/abs-image/US/2021/06/03/US20210163523A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to novel salts and crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate for use in treating viral infections. In some embodiments, the viral infection is caused by a virus selected from the group consisting of Arenaviridae, Coronaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae.
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