- 专利标题： TREATING LIVER DISEASE BY SELECTIVELY ELIMINATING SENESCENT CELLS
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申请号： US17114379申请日： 2020-12-07
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公开(公告)号： US20210169876A1公开(公告)日： 2021-06-10
- 发明人: Remi-Martin Laberge , Judith Campisi , Marco Demaria , Nathaniel David , James L. Kirkland , Tamar Tchkonia , Yi Zhu
- 申请人： Buck Institute for Research on Aging , Unity Biotechnology, Inc. , Mayo Foundation for Medical Education and Research
- 申请人地址： US CA Novato; US CA South San Francisco; US MN Rochester
- 专利权人： Buck Institute for Research on Aging,Unity Biotechnology, Inc.,Mayo Foundation for Medical Education and Research
- 当前专利权人： Buck Institute for Research on Aging,Unity Biotechnology, Inc.,Mayo Foundation for Medical Education and Research
- 当前专利权人地址： US CA Novato; US CA South San Francisco; US MN Rochester
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; A61P11/00 ; A61P9/10 ; A61P27/02 ; A61K31/428 ; A61K31/495 ; A61K31/5377 ; C12N15/113 ; A61P25/28 ; A61K47/68 ; A61K31/404 ; A61K31/4375 ; A61K45/06 ; A61K31/4178 ; A61K31/728 ; C12N5/00 ; A61K47/36 ; A61K9/00
摘要：
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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