A device for treatment and collection of saliva provides a base containing aa suction source. A tip having an inlet for collecting a saliva sample is removably attached to the base. A filter material, selected to allow passage of a target biomarker in the saliva sample, is disposed within the tip on a fluid path from the inlet. A collection chamber is disposed on the fluid path downstream of the filter material. The suction source is in fluid communication with the fluid path to draw saliva into the inlet of the tip, through the filter material, and to the collection chamber. Methods for collection of a saliva sample are also provided.