- 专利标题： COMPOSITIONS AND METHODS FOR IN SITU-FORMING TISSUE CONSTRUCTS
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申请号： US17251605申请日： 2019-06-27
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公开(公告)号： US20210244659A1公开(公告)日： 2021-08-12
- 发明人: David Myung , Sarah Hull , Sarah Heilshorn , Christopher Lindsay , Christopher Madl , Hyun Jong Lee
- 申请人： The Board of Trustees of the Leland Stanford Junior University , U.S. Government Represented by the Department of Veterans Affairs
- 申请人地址： US CA Stanford; US DC NW Washington
- 专利权人： The Board of Trustees of the Leland Stanford Junior University,U.S. Government Represented by the Department of Veterans Affairs
- 当前专利权人： The Board of Trustees of the Leland Stanford Junior University,U.S. Government Represented by the Department of Veterans Affairs
- 当前专利权人地址： US CA Stanford; US DC NW Washington
- 国际申请： PCT/US2019/039541 WO 20190627
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61F2/14 ; A61K9/06 ; A61K47/36 ; A61K47/10 ; A61K47/42
摘要：
Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined gel structure in situ. Such gels can serve as cellular or acellular lamellar substitutes to reconstruct corneal stroma, facilitate matrix remodeling, and support multilayered re-epithelialization of wounded corneal stromal tissue, as well delivery vehicles for cells, biomolecules, and/or pharmaceutical agents to wound sites throughout the body.