- 专利标题： ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF
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申请号： US17086699申请日： 2020-11-02
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公开(公告)号： US20210284652A1公开(公告)日： 2021-09-16
- 发明人: Andrew WASMUTH , Donald W. LANDRY
- 申请人： The Trustees of Columbia University in the City of New York
- 申请人地址： US NY New York
- 专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人： The Trustees of Columbia University in the City of New York
- 当前专利权人地址： US NY New York
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61P9/10 ; A61P25/02 ; A61P17/00 ; A61P13/12
摘要：
The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.
公开/授权文献
- US11498925B2 Aldose reductase inhibitors and methods of use thereof 公开/授权日：2022-11-15
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