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    ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF
    1.
    发明申请
    ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20190300543A1

    公开(公告)日：2019-10-03

    申请号：US16182169

    申请日：2018-11-06

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Andrew WASMUTH ,  Donald W. LANDRY

    IPC分类号： C07D495/04 ,  A61P13/12 ,  A61P9/10 ,  A61P25/02 ,  A61P17/00

    摘要： The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.

    ALDOSE REDUCTASE INHIBITORS AND USES THEREOF
    4.
    发明申请
    ALDOSE REDUCTASE INHIBITORS AND USES THEREOF 审中-公开

    公开(公告)号：US20200289512A1

    公开(公告)日：2020-09-17

    申请号：US16886165

    申请日：2020-05-28

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Andrew WASMUTH ,  Donald W. LANDRY ,  Shixian DENG ,  Banavara L. MYLARI ,  Ravichandran RAMASAMY ,  Ann Marie SCHMIDT

    IPC分类号： A61K31/5025 ,  C07D487/04

    摘要： The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, infections of the skin, peripheral vascular disease, stroke, and the like.

    ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF
    5.
    发明申请
    ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20210284652A1

    公开(公告)日：2021-09-16

    申请号：US17086699

    申请日：2020-11-02

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Andrew WASMUTH ,  Donald W. LANDRY

    IPC分类号： C07D495/04 ,  A61P9/10 ,  A61P25/02 ,  A61P17/00 ,  A61P13/12

    摘要： The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.

    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
    6.
    发明申请
    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF 有权

    公开(公告)号：US20210130349A1

    公开(公告)日：2021-05-06

    申请号：US17137665

    申请日：2020-12-30

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Donald W. LANDRY ,  Shixian DENG ,  Ottavio ARANCIO ,  Jole FIORITO ,  Andrew WASMUTH

    IPC分类号： C07D471/04 ,  C07D471/14

    摘要： The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibition of phosphodiesterase comprising contacting phosphodiesterase with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. The invention further provides for methods for treatment of neurodegenerative diseases, increasing memory or long term potentiation with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the phosphodiesterase is PDE5.

    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
    8.
    发明申请
    NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF 审中-公开
    新型磷酸酯酶抑制剂及其用途

    公开(公告)号：US20160152612A1

    公开(公告)日：2016-06-02

    申请号：US14905246

    申请日：2014-07-17

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Donald W. LANDRY ,  Shixian DENG ,  Ottavio ARANCIO ,  Jole FLORITO ,  Andrew WASMUTH

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04 ,  C07D471/14

    摘要： The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibition of phosphodiesterase comprising contacting phosphodiesterase with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. The invention further provides for methods for treatment of neurodegenerative diseases, increasing memory or long term potentiation with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the phosphodiesterase is PDE5.

    摘要翻译： 本发明提供新的苯并萘啶衍生物和包含新的苯并萘啶衍生物的组合物。 在一些实施方案中，化合物是磷酸二酯酶抑制剂。 本发明还提供了抑制磷酸二酯酶的方法，包括使磷酸二酯酶与新的苯并萘啶衍生物或包含新的苯并萘啶衍生物的组合物接触。 本发明进一步提供治疗神经变性疾病的方法，增加记忆力或使用新的苯并萘啶衍生物或包含新的苯并萘啶衍生物的组合物的长期增强作用。 在一些实施方案中，磷酸二酯酶是PDE5。

    ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF
    10.
    发明公开
    ALDOSE REDUCTASE INHIBITORS AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20230312599A1

    公开(公告)日：2023-10-05

    申请号：US18046205

    申请日：2022-10-13

    申请人： The Trustees of Columbia University in the City of New York

    发明人： Andrew WASMUTH ,  Donald W. LANDRY

    IPC分类号： C07D495/04 ,  A61P9/10 ,  A61P25/02 ,  A61P17/00 ,  A61P13/12

    CPC分类号： C07D495/04 ,  A61P9/10 ,  A61P25/02 ,  A61P17/00 ,  A61P13/12

    摘要： The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.