- 专利标题: ANTIBODY CONSTRUCTS FOR CD70 AND CD3
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申请号: US17084088申请日: 2020-10-29
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公开(公告)号: US20210284748A1公开(公告)日: 2021-09-16
- 发明人: Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
- 申请人: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
- 申请人地址: DE Munich; US CA Thousand Oaks
- 专利权人: AMGEN RESEARCH (MUNICH) GMBH,AMGEN INC.
- 当前专利权人: AMGEN RESEARCH (MUNICH) GMBH,AMGEN INC.
- 当前专利权人地址: DE Munich; US CA Thousand Oaks
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K16/30
摘要:
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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