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公开(公告)号：US20170129961A1
公开(公告)日：2017-05-11
申请号：US15225282
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
CPC分类号： C07K16/2875 , C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US10851170B2
公开(公告)日：2020-12-01
申请号：US15225282
申请日：2016-08-01
发明人： Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20210284748A1
公开(公告)日：2021-09-16
申请号：US17084088
申请日：2020-10-29
发明人： Tobias Raum , Claudia Blümel , Wibke Deisting , Patrick Hoffmann , Ralf Lutterbüse , Elisabeth Nahrwold , Olivier Nolan-Stevaux , Marc Panzer
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human CD70 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：US20180305465A1
公开(公告)日：2018-10-25
申请号：US15779325
申请日：2016-11-23
申请人： AMGEN INC. , XENCOR, INC.
发明人： Jennitte Leann Stevens , Mercedesz Balazs , Olivier Nolan-Stevaux , Gregory Moore , John Desjarlais , Matthew J. Bernett , Seung Y. Chu , Rumana Rashid , Umesh Muchhal
CPC分类号： C07K16/468 , A61K2039/505 , A61P35/00 , C07K16/2809 , C07K16/40 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
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公开(公告)号：US20240301087A1
公开(公告)日：2024-09-12
申请号：US18602865
申请日：2024-03-12
申请人： AMGEN INC. , XENCOR, INC.
发明人： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Campbell Graham , Jennitte LeAnn Stevens , Gregory Moore
CPC分类号： C07K16/3069 , A61P35/00 , C07K16/2809 , C07K16/2818 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US20230159656A1
公开(公告)日：2023-05-25
申请号：US18054426
申请日：2022-11-10
申请人： Amgen Inc.
发明人： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens
CPC分类号： C07K16/3069 , A61P35/00 , C07K16/2809 , C07K16/2818 , A61K2039/505
摘要： The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US11530274B2
公开(公告)日：2022-12-20
申请号：US16634571
申请日：2019-07-02
申请人： AMGEN INC. , XENCOR, INC.
发明人： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens , Gregory Moore
摘要： The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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公开(公告)号：US20210179731A1
公开(公告)日：2021-06-17
申请号：US16634571
申请日：2019-07-02
申请人： AMGEN INC. , XENCOR, INC.
发明人： Olivier Nolan-Stevaux , Cong Li , Christopher M. Murawsky , Benjamin M. Alba , Neeraj Jagdish Agrawal , Kevin Graham , Jennitte LeAnn Stevens , Gregory Moore
摘要： The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
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