A portable medical spray includes a tubular body having a room defined therein, and a breakable portion is formed to the top end of the body. A connection portion extends from the bottom end of the body. A nozzle is connected to the top end of the body. The nozzle has a passage which is located corresponding to the breakable portion. A medicine cell is located in the room of the body and has medicine received therein. The medicine cell is a compressible bellow cell. A needle is located in the medicine cell. An end part is mounted to the connection portion. The end part is pushed toward the nozzle to compress the medicine cell, and the needle penetrates through the top end of the medicine cell and the breakable portion to release the medicine via the nozzle.