- 专利标题： PROCESS FOR THE PREPARATION OF N-(4-(6,7-DIMETHOXYQUINOLIN-4-YLOXY) PHENYL)-N'-(4-FLUOROPHENYL)CYCLOPROPANE-1, 1-DICARBOXAMIDE, (2S)-HYDROXYBUTANEDIOATE AND ITS POLYMORPHS THEREOF
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申请号： US16467853申请日： 2017-12-06
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公开(公告)号： US20210403431A1公开(公告)日： 2021-12-30
- 发明人: THIRUMALAI RAJAN SRINIVASAN , ESWARAIAH SAJJA , VENKATA PANAKALA RAO GOGULAPATI , RAJESHWAR REDDY SAGYAM , SHYAM KIRAN BABU GANDHAM , RAJESHAM BOGE
- 申请人： THIRUMALAI RAJAN RAJAN Srinivasan , ESWARAIAH Sajja , VENKATA PANAKALA RAO Gogulapati , RAJESHWAR REDDY Sagyam , SHYAM KIRAN BABU Gandham , RAJESHAM Boge , MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
- 申请人地址： IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana
- 专利权人： THIRUMALAI RAJAN RAJAN Srinivasan,ESWARAIAH Sajja,VENKATA PANAKALA RAO Gogulapati,RAJESHWAR REDDY Sagyam,SHYAM KIRAN BABU Gandham,RAJESHAM Boge,MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
- 当前专利权人： THIRUMALAI RAJAN RAJAN Srinivasan,ESWARAIAH Sajja,VENKATA PANAKALA RAO Gogulapati,RAJESHWAR REDDY Sagyam,SHYAM KIRAN BABU Gandham,RAJESHAM Boge,MSN LABORATORIES PRIVATE LIMITED, R&D CENTER
- 当前专利权人地址： IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana; IN Medak (Dist), Telangana
- 优先权： IN201641041767 20161207,IN201741020998 20170615
- 国际申请： PCT/IN2017/000139 WO 20171206
- 主分类号： C07D215/233
- IPC分类号： C07D215/233
摘要：
The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
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