- 专利标题： Process for the preparation of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1, 1-dicarboxamide, (2S)-hydroxybutanedioate and its polymorphs thereof
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申请号： US16467853申请日： 2017-12-06
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公开(公告)号： US11261160B2公开(公告)日： 2022-03-01
- 发明人: Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
- 申请人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER , Thirumalai Rajan Srinivasan , Eswaraiah Sajja , Venkata Panakala Rao Gogulapati , Rajeshwar Reddy Sagyam , Shyam Kiran Babu Gandham , Rajesham Boge
- 申请人地址： IN Telangana; IN Hyderabad; IN Hyderabad; IN Hyderabad; IN Hyderabad; IN Hyderabad; IN Hyderabad
- 专利权人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER,Thirumalai Rajan Srinivasan,Eswaraiah Sajja,Venkata Panakala Rao Gogulapati,Rajeshwar Reddy Sagyam,Shyam Kiran Babu Gandham,Rajesham Boge
- 当前专利权人： MSN LABORATORIES PRIVATE LIMITED, R&D CENTER,Thirumalai Rajan Srinivasan,Eswaraiah Sajja,Venkata Panakala Rao Gogulapati,Rajeshwar Reddy Sagyam,Shyam Kiran Babu Gandham,Rajesham Boge
- 当前专利权人地址： IN Telangana; IN Hyderabad; IN Hyderabad; IN Hyderabad; IN Hyderabad; IN Hyderabad; IN Hyderabad
- 代理机构： IP Pundit LLC
- 优先权： IN201641041767 20161207,IN201741020998 20170615
- 国际申请： PCT/IN2017/000139 WO 20171206
- 国际公布： WO2018/104954 WO 20180614
- 主分类号： C07D215/233
- IPC分类号： C07D215/233
摘要：
The present invention also relates to process for the preparation of N-(4-(6,7-dimethoxy quinolin-4-yloxy)phenyl)-N′-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (S)-malate compound of formula-1a and its polymorphs thereof, represented by the following structural:
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