- 专利标题: Extended Release Highly Loaded Drug Compositions
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申请号: US17489137申请日: 2021-09-29
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公开(公告)号: US20220016035A1公开(公告)日: 2022-01-20
- 发明人: Liliana A. Miinea , Elena S. Draganoiu , Kedar V. Chikhalikar , Vikrant V. Chadawar
- 申请人: Lubrizol Advanced Materials, Inc.
- 申请人地址: US OH Cleveland
- 专利权人: Lubrizol Advanced Materials, Inc.
- 当前专利权人: Lubrizol Advanced Materials, Inc.
- 当前专利权人地址: US OH Cleveland
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K31/155 ; A61K31/4015
摘要:
The disclosed technology provides improved drug compositions that provide increased stability, higher drug loading potential, and suitable drug dissolution properties, and methods of making the same. The composition include: (a) a drug component comprising a therapeutically effective amount of a drug; (b) an extended release component comprising a cross-linked polyacrylic acid polymer that is a carbomer homopolymer, carbomer copolymer, carbomer interpolymer, polycarbophil or a mixture thereof; and (c) a buffering component comprising a magnesium containing buffering agent; wherein the drug component makes up at least 50% by weight of the composition.
公开/授权文献
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