公开(公告)号：US20220016035A1

公开(公告)日：2022-01-20

申请号：US17489137

申请日：2021-09-29

申请人： Lubrizol Advanced Materials, Inc.

发明人： Liliana A. Miinea ,  Elena S. Draganoiu ,  Kedar V. Chikhalikar ,  Vikrant V. Chadawar

IPC分类号： A61K9/20 ,  A61K31/155 ,  A61K31/4015

摘要： The disclosed technology provides improved drug compositions that provide increased stability, higher drug loading potential, and suitable drug dissolution properties, and methods of making the same. The composition include: (a) a drug component comprising a therapeutically effective amount of a drug; (b) an extended release component comprising a cross-linked polyacrylic acid polymer that is a carbomer homopolymer, carbomer copolymer, carbomer interpolymer, polycarbophil or a mixture thereof; and (c) a buffering component comprising a magnesium containing buffering agent; wherein the drug component makes up at least 50% by weight of the composition.