公开(公告)号：US20220304936A1

公开(公告)日：2022-09-29

申请号：US17635815

申请日：2020-08-28

申请人： LUBRIZOL ADVANCED MATERIALS, INC.

发明人： Elena S. Draganoiu ,  Barbara J. Morgan ,  David W. Weaver ,  Shreya P. Shah ,  Todd J. Wilson ,  Michael Grieco ,  Cynthia S. Randall ,  Kimberly A. Zubris ,  Mark A. Mitchnick ,  Liliana A. Miinea

IPC分类号： A61K9/20 ,  A61K31/427 ,  A61K31/496

摘要： An amorphous solid dispersion includes a linear poly(acrylic acid) and an active pharmaceutical ingredient. The linear poly(acrylic acid) used to form the amorphous solid dispersion has a Brookfield viscosity of at least 100 cP at 25° C. A method of forming such an amorphous solid dispersion of an active pharmaceutical ingredient includes forming a liquid dispersion of a linear poly(acrylic acid), an active pharmaceutical ingredient, and a solvent system, the linear poly(acrylic acid) having a Brookfield viscosity at 25° C. of at least 100 cP and evaporating the solvent system from the liquid dispersion to form an amorphous solid dispersion.

公开(公告)号：US20220016035A1

公开(公告)日：2022-01-20

申请号：US17489137

申请日：2021-09-29

申请人： Lubrizol Advanced Materials, Inc.

发明人： Liliana A. Miinea ,  Elena S. Draganoiu ,  Kedar V. Chikhalikar ,  Vikrant V. Chadawar

IPC分类号： A61K9/20 ,  A61K31/155 ,  A61K31/4015

摘要： The disclosed technology provides improved drug compositions that provide increased stability, higher drug loading potential, and suitable drug dissolution properties, and methods of making the same. The composition include: (a) a drug component comprising a therapeutically effective amount of a drug; (b) an extended release component comprising a cross-linked polyacrylic acid polymer that is a carbomer homopolymer, carbomer copolymer, carbomer interpolymer, polycarbophil or a mixture thereof; and (c) a buffering component comprising a magnesium containing buffering agent; wherein the drug component makes up at least 50% by weight of the composition.

公开(公告)号：US20220151879A1

公开(公告)日：2022-05-19

申请号：US17665139

申请日：2022-02-04

申请人： Lubrizol Advanced Materials, Inc.

发明人： Elena S. Draganoiu ,  Antonio Moroni

IPC分类号： A61K6/35 ,  C08L1/28 ,  C08L33/02

摘要： The disclosed technology provides improved adhesive composition of use with dentures. These improved compositions include (a) a cross linked poly(acrylic) acid polymer, in combination with (b) a carbomethylcellulose (CMC) component and/or (c) an adherence promoting component. The compositions balance the many competing goals for effective denture adhesives, including adhesive strength and dispensing viscosity, without the need for zinc.

公开(公告)号：US20200069533A1

公开(公告)日：2020-03-05

申请号：US16495441

申请日：2018-03-23

申请人： Lubrizol Advanced Materials, Inc.

发明人： Elena S. Draganoiu ,  Antonio Moroni

IPC分类号： A61K6/00 ,  C08L1/28 ,  C08L33/02

摘要： The disclosed technology provides improved adhesive composition of use with dentures. These improved compositions include (a) a cross linked poly(acrylic) acid polymer, in combination with (b) a carbomethylcellulose (CMC) component and/or (c) an adherence promoting component. The compositions balance the many competing goals for effective denture adhesives, including adhesive strength and dispensing viscosity, without the need for zinc.