发明申请
- 专利标题： HETERODIMER MOLECULE BASED ON CH3 DOMAIN, AND PREPARATION METHOD AND USE THEREOF
-
申请号： US17496240申请日： 2021-10-07
-
公开(公告)号： US20220017643A1公开(公告)日： 2022-01-20
- 发明人: Ting XU
- 申请人： JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD. , SUZHOU ALPHAMAB CO., LTD.
- 申请人地址： CN Suzhou; CN Suzhou
- 专利权人： JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD.,SUZHOU ALPHAMAB CO., LTD.
- 当前专利权人： JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO., LTD.,SUZHOU ALPHAMAB CO., LTD.
- 当前专利权人地址： CN Suzhou; CN Suzhou
- 优先权： CN201510938995.0 20151216
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; C12P21/00 ; C12N15/11 ; A61K39/395 ; C07K16/00 ; C07K19/00 ; C12N15/62
摘要：
The disclosure is directed to a heterodimer molecule, comprising a first polypeptide chain and a second polypeptide chain, and the first polypeptide chain comprises a first CH3 domain of an antibody heavy chain constant region, the second polypeptide chain comprises a second CH3 domain of an antibody heavy chain constant region. Comparing to a corresponding wild-type CH3 domain of a human antibody heavy chain constant region, the first CH3 domain and the second CH3 domain comprise amino acid mutations at specific positions, for example T366+K409+K392 and T366+L368+Y407+D399+F405, respectively.
信息查询
