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公开(公告)号：US20240076345A1
公开(公告)日：2024-03-07
申请号：US18270097
申请日：2021-12-27
发明人： Ting XU , Yuhao JIN , Xiaoxiao WANG , Pilin WANG , Qian LI
IPC分类号： C07K14/605 , A61K38/26 , A61P3/10
CPC分类号： C07K14/605 , A61K38/26 , A61P3/10 , C07K2319/30
摘要： A human GLP-1 polypeptide variant, and a fusion protein or an immunoconjugate constructed by means of using the human GLP-1 polypeptide variant can be used for preventing, and/or treating metabolic diseases or conditions related to GLP-1.
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公开(公告)号：US11377497B2
公开(公告)日：2022-07-05
申请号：US16479858
申请日：2018-01-23
发明人： Ting Xu , Aiwu Zhou , Yuhao Jin , Ling Wang , Jie Wu , Hongqin Hu , Xiaoxiao Wang
IPC分类号： C07K16/28 , C12N15/85 , A61K39/395 , G01N33/577 , G01N33/68
摘要： The present invention relates to the field of medical biology, and discloses a high-resolution crystal structure of a complex of PD-L1-blocking heavy-chain single-domain antibody KN035 binding with PD-L1, and the use of the crystal structure. The invention also relates to novel PD-L1 binding polypeptides or compounds developed based on the crystal structure and uses thereof.
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公开(公告)号：US20190031782A1
公开(公告)日：2019-01-31
申请号：US15541921
申请日：2016-01-08
发明人： Ting XU , Tau XU , Xiaoxiao WANG , Qian LI , Minjie PANG , Huimin ZHANG , Li HAN , Li HAN
摘要： The present application provides a bispecific antibody or an antibody mixture with common light chains and a preparation method therefor. the present application also provides a nucleic acid molecule encoding the antibody or the mixture, a recombinant vector and a recombinant cell comprising the nucleic acid molecule, as well as a detection and quantitation method for the antibody or the mixture.
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公开(公告)号：US09969786B2
公开(公告)日：2018-05-15
申请号：US14646926
申请日：2013-11-22
发明人： Ting Xu , Kangping Guo , Lihong Yun
CPC分类号： C07K14/59 , A61K38/00 , A61K38/24 , C07K2319/30
摘要： Disclosed herein is a gonadotropin fusion protein or a thyroid stimulating hormone fusion protein, a method for preparing the same and use thereof. β-subunit of the gonadotropin or thyroid stimulating hormone is fused to an Fc fragment directly or indirectly through a linker, and α-subunit binds to the β-subunit via an affinity between the α-subunit and the β-subunit. The fusion protein has a prolonged half-life and less fluctuating activity.
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公开(公告)号：US20220017643A1
公开(公告)日：2022-01-20
申请号：US17496240
申请日：2021-10-07
发明人： Ting XU
摘要： The disclosure is directed to a heterodimer molecule, comprising a first polypeptide chain and a second polypeptide chain, and the first polypeptide chain comprises a first CH3 domain of an antibody heavy chain constant region, the second polypeptide chain comprises a second CH3 domain of an antibody heavy chain constant region. Comparing to a corresponding wild-type CH3 domain of a human antibody heavy chain constant region, the first CH3 domain and the second CH3 domain comprise amino acid mutations at specific positions, for example T366+K409+K392 and T366+L368+Y407+D399+F405, respectively.
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6.发明授权公开(公告)号：US11225522B2
公开(公告)日：2022-01-18
申请号：US15748421
申请日：2016-08-01
发明人： Ting Xu , Yanrong Dong , Pilin Wang , Ting Chen
IPC分类号： C07K16/28 , A61K39/395 , C12N5/10 , C12N15/85 , A61P35/00 , A61K45/06 , C07K16/30 , A61K47/68 , G01N33/574 , A61K39/00 , A61N5/10
摘要： The present invention relates to the field of medical biology and discloses a single domain antibody and derivative proteins thereof against programmed death ligand (PDL1). In particular, the present invention discloses a programmed death ligand 1 (PDL1) binding molecule and the use thereof, especially the use for treating and/or preventing or diagnosing PDL1 relevant diseases such as tumor.
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公开(公告)号：US20190315864A1
公开(公告)日：2019-10-17
申请号：US16302583
申请日：2017-05-19
摘要： The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.
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公开(公告)号：US20190055295A1
公开(公告)日：2019-02-21
申请号：US15978857
申请日：2018-05-14
发明人： Ting XU , Kangping GUO , Lihong YUN
摘要： Disclosed herein is a gonadotropin fusion protein or a thyroid stimulating hormone fusion protein, a method for preparing the same and use thereof. β-subunit of the gonadotropin or thyroid stimulating hormone is fused to an Fc fragment directly or indirectly through a linker, and α-subunit binds to the β-subunit via an affinity between the α-subunit and the β-subunit. The fusion protein has a prolonged half-life and less fluctuating activity.
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公开(公告)号：US20240247076A1
公开(公告)日：2024-07-25
申请号：US18014318
申请日：2021-07-02
发明人： Ting XU , Xiaoxiao WANG , Yuhao JIN , Kangping GUO , Ling WANG , Minjie PANG , Pilin WANG
CPC分类号： C07K16/36 , A61P7/02 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/90
摘要： The present invention relates to the pharmaceutical and biological field, and discloses a single-domain antibody against coagulation factor XI (FXI) and derived protein thereof. In particular, the present invention discloses a coagulation factor XI (FXI) binding protein derived from a single-domain antibody against coagulation factor XI (FXI) and use thereof.
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公开(公告)号：US11912768B2
公开(公告)日：2024-02-27
申请号：US17369169
申请日：2021-07-07
IPC分类号： C07K16/00 , C07K16/28 , A61P35/00 , A61K39/395 , C07K16/22 , C07K16/32 , C12N15/70 , A61K39/00
CPC分类号： C07K16/2818 , A61K39/3955 , A61K39/39558 , A61P35/00 , C07K16/22 , C07K16/2863 , C07K16/32 , C12N15/70 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/569
摘要： The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.
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