The present disclosure relates to a security inspection device and a transfer method, and the security inspection device includes an arm frame, provided with detectors, and configured to form an inspection channel; a first compartment, internally provided with a radiation source and connected with the arm frame, a protection wall, connected with the first compartment or the arm frame, and configured to perform radiation protection for an object to be protected, and a tire assembly, configured to enable the security inspection device to move relative to the ground, and the arm frame, the first compartment, the protection wall and the tire assembly are set to be transported together in a connected state.