- 专利标题： ACETAMIDO-PHENYLBENZAMIDE DERIVATIVES AND METHODS OF USING THE SAME
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申请号： US17495933申请日： 2021-10-07
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公开(公告)号： US20220106301A1公开(公告)日： 2022-04-07
- 发明人: Sameer URGAONKAR , Ahmed M. SAID , Nader N. NASIEF ABDEL SAYED , Laura Beth PITZONKA , Murray John CUTLER , Michael P. SMOLINSKI , Johnson Yiu-Nam LAU
- 申请人： Athenex, Inc.
- 申请人地址： US NY Buffalo
- 专利权人： Athenex, Inc.
- 当前专利权人： Athenex, Inc.
- 当前专利权人地址： US NY Buffalo
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07D401/12 ; C07D311/22 ; C07D405/14 ; C07D407/12 ; C07D401/14 ; C07D409/14 ; C07D417/14 ; C07D417/12
摘要：
The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for the treatment of disorders in which expression of P-glycoprotein and/or cytochrome P450 (e.g., CYP3A4) is modulated (e.g., cancers which have developed multi-drug resistance).