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公开(公告)号:US20210347763A1
公开(公告)日:2021-11-11
申请号:US17114699
申请日:2020-12-08
申请人: Athenex, Inc.
IPC分类号: C07D403/14 , C07D403/12 , A61P37/08 , A61P37/02
摘要: The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.
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公开(公告)号:US20220106312A1
公开(公告)日:2022-04-07
申请号:US17495935
申请日:2021-10-07
申请人: Athenex, Inc.
发明人: Sameer URGAONKAR , Ahmed M. SAID , Nader N. NASIEF ABDEL SAYED , Laura Beth PITZONKA , Murray John CUTLER , Michael P. SMOLINSKI , Johnson Yiu-Nam LAU
IPC分类号: C07D471/04 , C07D487/06 , C07D405/14 , C07D401/14 , A61P35/00
摘要: The present disclosure relates to compounds of Formula (IA) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for the treatment of disorders in which P-glycoprotein and/or cytochrome P450 (e.g. CYP3A4) is modulated (e.g., cancers which have developed multi-drug resistance).
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公开(公告)号:US20180265499A1
公开(公告)日:2018-09-20
申请号:US15921890
申请日:2018-03-15
申请人: Athenex, Inc.
IPC分类号: C07D403/14 , C07D403/12 , A61P37/02 , A61P37/08
CPC分类号: C07D403/14 , A61P37/02 , A61P37/08 , C07D211/40 , C07D403/12
摘要: The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.
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公开(公告)号:US20220106301A1
公开(公告)日:2022-04-07
申请号:US17495933
申请日:2021-10-07
申请人: Athenex, Inc.
发明人: Sameer URGAONKAR , Ahmed M. SAID , Nader N. NASIEF ABDEL SAYED , Laura Beth PITZONKA , Murray John CUTLER , Michael P. SMOLINSKI , Johnson Yiu-Nam LAU
IPC分类号: C07D405/12 , C07D401/12 , C07D311/22 , C07D405/14 , C07D407/12 , C07D401/14 , C07D409/14 , C07D417/14 , C07D417/12
摘要: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for the treatment of disorders in which expression of P-glycoprotein and/or cytochrome P450 (e.g., CYP3A4) is modulated (e.g., cancers which have developed multi-drug resistance).
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公开(公告)号:US20200071305A1
公开(公告)日:2020-03-05
申请号:US16567300
申请日:2019-09-11
申请人: Athenex, Inc.
IPC分类号: C07D403/14 , A61P37/02 , A61P37/08 , C07D403/12
摘要: The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.
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