- 专利标题： GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME
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申请号： US17566919申请日： 2021-12-31
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公开(公告)号： US20220119377A1公开(公告)日： 2022-04-21
- 发明人: Brian M. Stoltz , Alexander W. Sun , Stephan N. Hess , Carina I. Jette , Irina Geibel , Shoshana Bachman , Masaki Hayashi , Hideki Shimizu , Jeremy B. Morgan , Shunya Sakurai , Zachary P. Sercel
- 申请人： California Institute of Technology
- 申请人地址： US CA Pasadena
- 专利权人： California Institute of Technology
- 当前专利权人： California Institute of Technology
- 当前专利权人地址： US CA Pasadena
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; C07D207/26 ; C07D243/08 ; C07D239/06 ; C07D507/00 ; C07D241/08
摘要：
Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
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