专利检索 ap:("California Institute of Technology") AND inv:"Jeremy B. Morgan" 第 1 页

1.

发明申请
GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME 有权

公开(公告)号：US20220119377A1

公开(公告)日：2022-04-21

申请号：US17566919

申请日：2021-12-31

申请人： California Institute of Technology

发明人： Brian M. Stoltz , Alexander W. Sun , Stephan N. Hess , Carina I. Jette , Irina Geibel , Shoshana Bachman , Masaki Hayashi , Hideki Shimizu , Jeremy B. Morgan , Shunya Sakurai , Zachary P. Sercel

IPC分类号： C07D413/14 , C07D207/26 , C07D243/08 , C07D239/06 , C07D507/00 , C07D241/08

摘要： Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).

2.

发明申请
GEM-DISUBSTITUTED PYRROLIDINES, PIPERAZINES, AND DIAZEPANES, AND COMPOSITIONS AND METHODS OF MAKING THE SAME 有权

公开(公告)号：US20220213081A1

公开(公告)日：2022-07-07

申请号：US17566915

申请日：2021-12-31

申请人： California Institute of Technology

发明人： Brian M. Stoltz , Alexander W. Sun , Stephan N. Hess , Carina I. Jette , Irina Geibel , Shoshana Bachman , Masaki Hayashi , Hideki Shimizu , Jeremy B. Morgan , Shunya Sakurai , Zachary P. Sercel

IPC分类号： C07D413/14 , C07D207/26 , C07D243/08 , C07D239/06 , C07D507/00 , C07D241/08

摘要： Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).

3.

发明授权
Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same 有权

公开(公告)号：US11214568B2

公开(公告)日：2022-01-04

申请号：US16657672

申请日：2019-10-18

申请人： California Institute of Technology

发明人： Brian M. Stoltz , Alexander W. Sun , Stephan N. Hess , Carina I. Jette , Irina Geibel , Shoshana Bachman , Masaki Hayashi , Hideki Shimizu , Jeremy B. Morgan , Shunya Sakurai , Zachary P. Sercel

IPC分类号： C07D243/08 , C07D413/14 , C07D207/26 , C07D239/06 , C07D507/00 , C07D241/08

摘要： Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).