公开(公告)号：US11214568B2

公开(公告)日：2022-01-04

申请号：US16657672

申请日：2019-10-18

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Alexander W. Sun ,  Stephan N. Hess ,  Carina I. Jette ,  Irina Geibel ,  Shoshana Bachman ,  Masaki Hayashi ,  Hideki Shimizu ,  Jeremy B. Morgan ,  Shunya Sakurai ,  Zachary P. Sercel

IPC: C07D243/08 ,  C07D413/14 ,  C07D207/26 ,  C07D239/06 ,  C07D507/00 ,  C07D241/08

Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).

公开(公告)号：US20220119377A1

公开(公告)日：2022-04-21

申请号：US17566919

申请日：2021-12-31

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Alexander W. Sun ,  Stephan N. Hess ,  Carina I. Jette ,  Irina Geibel ,  Shoshana Bachman ,  Masaki Hayashi ,  Hideki Shimizu ,  Jeremy B. Morgan ,  Shunya Sakurai ,  Zachary P. Sercel

IPC: C07D413/14 ,  C07D207/26 ,  C07D243/08 ,  C07D239/06 ,  C07D507/00 ,  C07D241/08

Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).

公开(公告)号：US20220106325A1

公开(公告)日：2022-04-07

申请号：US17263453

申请日：2019-07-26

Applicant: California Institute of Technology ,  The Regents Of The University Of California ,  1200 Pharma LLC

Inventor： Brendan M. O'Boyle ,  Justin A. Hilf ,  Scott C. Virgil ,  Alexander W. Sun ,  Brian M. Stoltz ,  Dylan Conklin ,  Martina S. McDermott ,  Neil A. O'Brien ,  Michael J. Palazzolo ,  Dennis Slamon ,  Michael D. Bartberger

IPC: C07D491/107 ,  C07D413/14 ,  C07D498/10 ,  C07D401/14 ,  C07D495/10 ,  A61P35/00

Abstract: The present disclosure provides compounds and compositions that are CDK inhibitors selective for CDK4 and/or CDK6, and methods of use thereof.

公开(公告)号：US20220213081A1

公开(公告)日：2022-07-07

申请号：US17566915

申请日：2021-12-31

Applicant: California Institute of Technology

Inventor： Brian M. Stoltz ,  Alexander W. Sun ,  Stephan N. Hess ,  Carina I. Jette ,  Irina Geibel ,  Shoshana Bachman ,  Masaki Hayashi ,  Hideki Shimizu ,  Jeremy B. Morgan ,  Shunya Sakurai ,  Zachary P. Sercel

IPC: C07D413/14 ,  C07D207/26 ,  C07D243/08 ,  C07D239/06 ,  C07D507/00 ,  C07D241/08

Abstract: Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).