- 专利标题： MODULATION OF DENDRITIC CELL LINEAGES
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申请号： US17292017申请日： 2019-11-07
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公开(公告)号： US20220119472A1公开(公告)日： 2022-04-21
- 发明人: Nikolai KLEY , Jan TAVERNIER , Anje CAUWELS , Lennart ZABEAU , Erik DEPLA
- 申请人： Orionis Biosciences, Inc. , Orionis Biosciences BV , VIB VZW , Universiteit Gent
- 申请人地址： US MA Waltham; BE Chent; BE Gent; BE Gent
- 专利权人： Orionis Biosciences, Inc.,Orionis Biosciences BV,VIB VZW,Universiteit Gent
- 当前专利权人： Orionis Biosciences, Inc.,Orionis Biosciences BV,VIB VZW,Universiteit Gent
- 当前专利权人地址： US MA Waltham; BE Chent; BE Gent; BE Gent
- 国际申请： PCT/US19/60291 WO 20191107
- 主分类号： C07K14/56
- IPC分类号： C07K14/56 ; C07K16/28 ; A61P35/00 ; C07K14/565
摘要：
The present invention relates, in part, to agents, chimeric proteins and chimeric protein complexes that bind a plasmacytoid dendritic cell (pDC), e.g. Clec4C and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the pDC, e.g. Clec4C, binding agents, chimeric proteins, or chimeric protein complexes and their use in the treatment of various diseases, including autoimmune diseases.