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公开(公告)号:US11498966B2
公开(公告)日:2022-11-15
申请号:US16636501
申请日:2018-08-08
发明人: Nikolai Kley , Jan Tavernier , Lennart Zabeau , Erik Depla
IPC分类号: C07K16/28 , A61P35/00 , A61K39/00 , C07K14/56 , C07K14/565
摘要: The present invention relates, in part, to agents that bind PD-1 or PD-L1 and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the PD-1 or PD-L1 binding agents and their use in the treatment of various diseases.
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公开(公告)号:US20220249609A1
公开(公告)日:2022-08-11
申请号:US17620329
申请日:2020-06-18
发明人: Nikolai KLEY , Jan TAVERNIER , Leander HUYGHE
摘要: The present invention relates, in part, to chimeric protein or chimeric protein complex comprising a CD13 targeting moiety and a signaling agent (e.g., without limitation TNF or IFN-γ) and methods of treatment using such compositions.
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公开(公告)号:US20220119472A1
公开(公告)日:2022-04-21
申请号:US17292017
申请日:2019-11-07
发明人: Nikolai KLEY , Jan TAVERNIER , Anje CAUWELS , Lennart ZABEAU , Erik DEPLA
IPC分类号: C07K14/56 , C07K16/28 , A61P35/00 , C07K14/565
摘要: The present invention relates, in part, to agents, chimeric proteins and chimeric protein complexes that bind a plasmacytoid dendritic cell (pDC), e.g. Clec4C and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the pDC, e.g. Clec4C, binding agents, chimeric proteins, or chimeric protein complexes and their use in the treatment of various diseases, including autoimmune diseases.
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公开(公告)号:US20200308244A1
公开(公告)日:2020-10-01
申请号:US16832995
申请日:2020-03-27
发明人: Nikolai KLEY , Erik DEPLA , Lennart ZABEAU , Jan TAVERNIER
摘要: The present invention relates, in part, to chimeric proteins or chimeric protein complexes, such as Fc-based chimeric protein complexes, comprising interferon alpha 1, or a variant thereof, and their use as therapeutic agents.
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公开(公告)号:US20230116707A1
公开(公告)日:2023-04-13
申请号:US17785676
申请日:2020-12-17
发明人: Nikolai KLEY , Samuel LIEVENS
IPC分类号: G01N33/68 , C12N15/10 , C07K14/715 , C07K14/71 , C07K14/72 , C07K14/705 , C12N9/10
摘要: The present invention is related to a method for detecting and identifying protein-protein or protein-small molecule interactions using a bait and prey system. It is also related to bait and prey proteins, small molecules and constructs that are used for the methods described herein.
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公开(公告)号:US20230020607A1
公开(公告)日:2023-01-19
申请号:US17785181
申请日:2020-12-15
发明人: Nikolai KLEY , Samuel LIEVENS , Riccardo SABATINI
IPC分类号: G01N33/566 , C07K14/005 , C07K14/47 , C12N9/10 , C12N9/00 , G01N33/50
摘要: Methods of assessing the efficacy of an agent in treating a disease or disorder are provided that include determining whether the agent causes, or inhibits, direct or indirect recruitment and/or ubiquitination and/or degradation of argininosuccinate synthetase 1 (ASS1).
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公开(公告)号:US20220026439A1
公开(公告)日:2022-01-27
申请号:US17415248
申请日:2019-12-19
发明人: Nikolai KLEY , Samuel LIEVENS , Riccardo SABATINI
IPC分类号: G01N33/68 , G01N33/543
摘要: The present invention relates to the use of a particle, including a virus-like particle (VLP), for the discovery and analysis of protein-protein interactions that are modulated by small molecules.
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公开(公告)号:US20210024637A1
公开(公告)日:2021-01-28
申请号:US16636250
申请日:2018-08-08
发明人: Nikolai KLEY , Jan TAVERNIER , Lennart ZABEAU , Erik DEPLA
摘要: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.
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公开(公告)号:US20210023167A1
公开(公告)日:2021-01-28
申请号:US16967288
申请日:2019-02-05
发明人: Nikolai KLEY , Jan TAVERNIER , Anje CAUWELS
IPC分类号: A61K38/16 , C07K14/555 , A61K31/704
摘要: The present invention relates, in part, to agents that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the FAP binding agents and their use in the treatment of various diseases.
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公开(公告)号:US20200231674A1
公开(公告)日:2020-07-23
申请号:US16634325
申请日:2018-08-08
发明人: Nikolai KLEY , Jan TAVERNIER , Lennart ZABEAU , Erik DEPLA
摘要: The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.
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