A system-on-chip with runtime global push to persistence includes a data processor having a cache, an external memory interface, and a microsequencer. The external memory interface is coupled to the cache and is adapted to be coupled to an external memory. The cache provides data to the external memory interface for storage in the external memory. The microsequencer is coupled to the data processor. In response to a trigger signal, the microsequencer causes the cache to flush the data by sending the data to the external memory interface for transmission to the external memory.