Invention Application
- Patent Title: COMPOSITION
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Application No.: US17441519Application Date: 2020-03-22
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Publication No.: US20220162335A1Publication Date: 2022-05-26
- Inventor: Cheng-I WANG , Bei WANG , Zi Xian Eve NGOH , Wen-Hsin LEE , Ching-Wen HUANG , Yee Chin, Yvonne YEAP
- Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Applicant Address: SG Connexis
- Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee Address: SG Connexis
- Priority: SG10201902550P 20190321
- International Application: PCT/SG2020/050152 WO 20200322
- Main IPC: C07K16/30
- IPC: C07K16/30 ; C07K16/28 ; C07K14/725 ; A61K39/395 ; A61K38/17 ; A61K47/68 ; A61P35/00

Abstract:
We describe an antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) sequence and a light chain variable region (VL) sequence of a clone selected from: 5C4, 4H1, 1D2, 1C4, 2B5, 1F1, 1H1, 4A5, 1D8, 1D3, 2F1, 3C6, 3D12, 3A9, 1F4, 1H10, 3C12, 4G11, 4A12, 1A12, 3G12, 4F9, 4G4 and 1E1 which is capable of specifically binding to glypican-3 (GPC-3) (GenBank Accession Number: NP_004475.1), or a sequence having at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity thereto.
Information query