公开(公告)号：US20220162335A1

公开(公告)日：2022-05-26

申请号：US17441519

申请日：2020-03-22

申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

发明人： Cheng-I WANG ,  Bei WANG ,  Zi Xian Eve NGOH ,  Wen-Hsin LEE ,  Ching-Wen HUANG ,  Yee Chin, Yvonne YEAP

IPC分类号： C07K16/30 ,  C07K16/28 ,  C07K14/725 ,  A61K39/395 ,  A61K38/17 ,  A61K47/68 ,  A61P35/00

摘要： We describe an antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) sequence and a light chain variable region (VL) sequence of a clone selected from: 5C4, 4H1, 1D2, 1C4, 2B5, 1F1, 1H1, 4A5, 1D8, 1D3, 2F1, 3C6, 3D12, 3A9, 1F4, 1H10, 3C12, 4G11, 4A12, 1A12, 3G12, 4F9, 4G4 and 1E1 which is capable of specifically binding to glypican-3 (GPC-3) (GenBank Accession Number: NP_004475.1), or a sequence having at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity thereto.

公开(公告)号：US20230080224A1

公开(公告)日：2023-03-16

申请号：US17798025

申请日：2021-02-05

申请人： Agency for Science, Technology and Research

发明人： William SUN ,  Boon Ooi Patrick TAN ,  Huajing WANG ,  Thai Leong YAP ,  Shin Yee HONG ,  Cheng-I WANG ,  Ching-Wen HUANG ,  Shuet Theng LEE ,  Kah Fei WAN ,  Jian Duan Johnathan NG

IPC分类号： C07K16/40 ,  G01N33/573 ,  G01N33/574 ,  A61P35/00

摘要： The invention relates to antigen-binding molecules that specifically binds ALPPL2 and/or ALPP but not ALPL or ALPI. It also relates to a pharmaceutical composition, an immunoconjugate and a chimeric antigen receptor comprising said antigen-binding molecules. The invention also relates to methods for reducing the expression or activity of ALPPL2 in a cancer cell and methods of treating a cancer in a subject.