Invention Application
- Patent Title: T7 RNA POLYMERASE VARIANTS
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Application No.: US17558454Application Date: 2021-12-21
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Publication No.: US20220186197A1Publication Date: 2022-06-16
- Inventor: Mathew G. Miller , Chinping Chng , Oscar Alvizo , Melissa Ann Mayo , James Nicholas Riggins , Xiang Yi , Jonathan S. Penfield , Gjalt W. Huisman , Jared Davis , Yasushi Saotome
- Applicant: Codexis, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12P19/34
Abstract:
The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
Public/Granted literature
- US12129494B2 T7 RNA polymerase variants Public/Granted day:2024-10-29
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